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Major Birth Defects Associated With Use Of Paxil During Pregnancy

Paxil dosagesThe medical evidence is mounting against pharmaceutical giant, GlaxoSmithKilne (GSK), regarding its knowledge of the increased rate of birth defects in children born to women who used Paxil during their pregnancy.

Paxil is a commonly prescribed antidepressant drug that has been used by millions of people.  Paxil is part of a well known group of drugs known as serotonin reuptake inhibitors (SSRI’s) that includes other anti-depressants such as Zoloft and Prozac.

As we learn more about GSK’s knowledge of the dangers associated with the use of Paxil (also referred to as paroxetine) during pregnancy, over the past few years the Food and Drug Administration has issued several warnings regarding Paxil usage during all phases of pregnancy.

Birth Defects Associated With Paxil

The most prominent birth defects associated with the use of Paxil include atrial septal defects (ASD) and ventral septal defects (VSD)– essentially heart and lung problems. Currently, research is underway to learn more about about Paxil’s effects on the developing fetus during the various stages of pregnancy.

There does appear to be a correlation between Paxil use and the following other birth defects:

  • Spina Bifida
  • Persistent Pulmonary Hypertension (PPHN)
  • Cranial Birth Defects
  • Neural Tube Defects
  • Deformed Limbs
  • Heart Valve Defects- atrial septal defects (ASD) an ventral septal defects (VSD)

Paxil Lawsuits Against GSK

Given the severity of the birth defects asscoiated with Paxil use and the fact that GSK failed to warn consumers about the potential problems, a number of lawsuits have already been against the drug maker.

Currently, there is no ‘class’ of that has been formed to pursue a case against GlaxoSmithKline.  Rather, lawsuits are permitted to proceed individually against the manufacturer.  Of the more than 800 indivudally filed lawsuits, GSK has already paid more than $1 billion to resolve a number of them.

If you were prescribed Paxil during a pregnancy and believe your child may have sustained birth defects, you may have legal rights for damages related to past and future medical expenses as well as other damages pursuant to the laws in the jurisdiction.  We would honor the opportunity to speak to you regarding your legal rights.  (888) 424-5757


Evaluation of the Risk of Congenital Cardiovascular Defects Associated With Use of Paroxetine During Pregnancy — Einarson et al. 165 (6): 749 — Am J Psychiatry (PDF)

Use of Selective Serotonin-Reuptake Inhibitors in Pregnancy and the Risk of Birth Defects (PDF) The New England Journal Of Medicine, June 28, 2007 Sura Alwan, M.Sc., Jennita Reefhuis, Ph.D., Sonja A. Rasmussen, M.D., M.S., Richard S. Olney, M.D., M.P.H., and Jan M. Friedman, M.D., Ph.D., for the National Birth Defects Prevention Study

Congenital Heart Disease Associated With Selective Serotonin Reuptake Inhibitor Use During Pregnancy — Mayo Clinic Proceedings (PDF) By CHRISTINA L. WICHMAN, DO; KATHERINE M. MOORE, MD; TARA R. LANG, MD; JENNIFER L. ST. SAUVER, PHD; ROBERT H. HEISE JR, MD; AND WILLIAM J. WATSON, MD

FDA: Information for Healthcare Professionals: Paroxetine (marketed as Paxil) July, 2006

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